[1]张 雄,马柏林*,樊 朋,等.微波辐射合成2″-硝基-2-苯基-1H,1’H-[2’,5]-双苯并咪唑[J].西北林学院学报,2014,29(01):127-130.[doi:10.3969/j.issn.1001-7461.2014.01.25]
 ZHANG Xiong,MA Bai-lin*,FAN Peng,et al.Synthesis of 2″-nitro-2-phenyl-1H,1’H-[2’,5]-bibenzimidazolyl with Microwave Radiation[J].JOURNAL OF NORTHWEST FORESTRY UNIVERSITY,2014,29(01):127-130.[doi:10.3969/j.issn.1001-7461.2014.01.25]
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微波辐射合成2″-硝基-2-苯基-1H,1’H-[2’,5]-双苯并咪唑()
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《西北林学院学报》[ISSN:1001-7461/CN:61-1202/S]

卷:
第29卷
期数:
2014年01期
页码:
127-130
栏目:
林业化学
出版日期:
2014-01-21

文章信息/Info

Title:
Synthesis of 2″-nitro-2-phenyl-1H,1’H-[2’,5]-bibenzimidazolyl with Microwave Radiation
文章编号:
1001-7461(2014)01-0127-04
作者:
张 雄马柏林*樊 朋高娟丽
西北农林科技大学 理学院,陕西 杨陵 712100
Author(s):
ZHANG XiongMA Bai-lin*FAN PengGAO Juan-li
College of Sciences,Northwest A&F University,Yangling,Shaanxi 712100,China
关键词:
2″-硝基-2-苯基-1H1’H-[2’5]-双苯并咪唑 合成 微波
Keywords:
2″-nitro-2-phenyl-1H 1’H-[2’5]-bibenzimidazolyl synthesis microwave
分类号:
S718.43
DOI:
10.3969/j.issn.1001-7461.2014.01.25
文献标志码:
A
摘要:
以3,4-二氨基苯甲酸与邻硝基苯甲醛为原料,借助微波辐射,合成了2″-硝基-2-苯基-1H,1’H-[2’,5]-双苯并咪唑。研究了物料比、微波辐射功率、辐射时间以及催化剂PPA与HCl比例对反应产率的影响。结果表明,第1步反应较佳条件为3,4-二氨基苯甲酸︰邻硝基苯甲醛=1︰1.3,微波辐射功率320 W,间歇辐射30 min,收率91%; 第2步反应较佳条件为2-(2-硝基苯基)-1H-苯并咪唑-5-甲酸︰邻苯二胺=1︰1.2,PPA︰HCl=1︰1,微波辐射功率500 W,间歇辐射15 min,收率92%。
Abstract:
The synthesis of 2″-nitro-2-phenyl-1H,1’H-[2’,5]-bibenzimidazolyl under microwave irradiation by using 3,4-diaminobenzoic acid and o-nitrylbenzaldehyde as reactants was reported.The influences of the mole ratio of reactants,output power of microwave generator,reaction time and the ratio of catalysts(PPA and HCl)on the yield were investigated.For the reactions of the first step,optimal reaction conditions were obtained as the ratio of 3,4-diaminobenzoic acid to o-nitrylbenzaldehyde:1:1.3,output power of microwave generator: 320 W,intermittent radiation time: 30 min.For the second step reaction,the optimal reaction conditions were as the ratio of 2-(2-Nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid to o-phenylenediamine: 1:1.2,the ratio of PPA to HCl: 1:1,output power: 500 W,intermittent radiation time:15 min.

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备注/Memo

备注/Memo:
收稿日期:2013-04-26 修回日期:2013-06-08
基金项目:国家林业局948项目(2008-4-43)。
作者简介:张雄,男,硕士研究生,研究方向:天然产物化学。E-mail: zhangxiong 281@163.com
*通信作者:马柏林,男,教授,研究方向:天然产物化学。E-mail: mbllsf-001@163.com
更新日期/Last Update: 2014-01-20